Today I learned responses to in vivo engineered CAR T cells are delayed compared to ex vivo engineered CAR T cells. Which makes sense because in vivo has fewer transduced cells which require more time for expansion.
“in vivo has fewer transduced cells which require more time for expansion”
“처음 만들어지는 CAR-T 숫자가 적으니까, 임상적으로 효과를 낼 만큼 군대가 불어나는 데 시간이 더 걸린다”
느린 expansion이 급격한 면역 활성화를 줄여 안전성에 도움이 될 가능성은 있다